Imagine it's the weekend, and we're all about hanging out with friends, hitting the bar, and having a good time with some drinks to chill after a week of work. But, we know too much drinking isn't great for our bodies.

Scientists are curious about how we can enjoy our drinks more safely and maybe even fix some of the harm they can do. There are lots of supplements out there claiming to be good for you, like vitamins, plant extracts, and synthetic versions of natural stuff. But when it comes to how these things affect our genes, it gets a bit complicated.

One interesting thing they looked at is curcumin, which is in turmeric. Studies have shown it can protect mouse livers from the damage caused by too much alcohol. To understand this better, they used bees as a model to see how certain things affect their lifespan and genes.

In this study, they did three steps. First, they picked seven things related to what we eat, like vitamins and stuff you might find in medicine. They checked how these things affected how long bees lived. Then, they focused on the ones that seemed the most promising to see how they changed the bees' genes.

The results showed that some of these things had a big impact on the bees' survival. For example, isovaleric acid, valproic acid, cyanocobalamin (vitamin B12), and folic acid all made a difference. Some made bees live longer at low amounts but shorter at higher amounts.

Now, when it comes to the alcohol we love, previous studies hinted that even a bit could make bees live less. This study found that even 1% was worse than we thought.

But, here's the cool part. When they mixed high amounts of curcumin and alcohol in the bees' diet, the bees lived longer compared to those just fed alcohol. It seems like curcumin could balance out the bad effects of alcohol on how long the bees lived.

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They also checked how these things affected something called DNA methylation, which is like a switch for our genes. Most of the things they tested didn't change it much. But when they gave bees only alcohol, it seemed to make more of this methylation happen. The interesting part is that when they added curcumin, it stopped this from happening.

Looking at specific parts of DNA affected by alcohol, they found that curcumin and alcohol together had a protective effect. It kept the DNA levels similar to bees not exposed to alcohol. This suggests that curcumin might stop the DNA changes caused by alcohol.

In simple terms, this study tells us that some things in our food can change how long bees live. The bad effects of alcohol on their lifespan might happen through changes in DNA. But, when you throw curcumin into the mix, it seems to prevent these changes. This research not only shows how curcumin can help bees live longer but also uses bees to understand how our DNA changes with alcohol.